Peptide Database

Peptide NameSLAY-screened peptide P593

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H157N27O32

DescriptionStandard

        TPLNYSVRNPHFTIDVPYTS
    

Molecular Weight2321.54 Da

Isoelectric Point (pI)6.41

Net Charge (pH 7.0)-0.52

Net Charge (pH 7.4) -0.76

Charge Density (pH 7.0) -0.0258

GRAVY Index-0.49

Hydrophobic Moment 0.40

Boman Index0.04

Instability Index14.43

Aliphatic Index 68.00

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 945.52

LogP -9.75

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 65.0

Heavy Atoms 165.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064079 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/