‹ ›
MYP_076101
← PREVIOUS NEXT → BACK
Basic Information
Esculentin (1-18)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C88H155N23O22
Standard
Sequence
GIFSKLAGKKLKNLLISG
Physicochemical Analysis
1887.31 Da
10.48
3.76
3.55
0.2087
0.38
0.57
0.17
-14.14
135.56
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
745.65
-5.55
26.0
26.0
69.0
133.0
1.0
18.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0065491 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa 2
16 μM
MIC
PMID32722535;20606068;25959536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
RECORD: Rec_0079132 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Murine macrophage cells RAW 264.7 20-30% Killing
64 μM
PMID32722535;20606068;25959536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
RECORD: Rec_0081958 VERIFIED: YES
Provenance & Taxonomy
Escherichia coli [Bacterium]
562;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMarcellini L., Borro M., Gentile G., Rinaldi A. C., Stella L., Aimola P., Barra D., Mangoni M. L.. Esculentin-1b(1-18)-a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli. FEBS J., 276, 5647-5664, 2009.
RECORD: Rec_0113667 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 15692
8 μM
MIC
PMID32722535;20606068;25959536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
RECORD: Rec_0115170 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
sheep red blood cells
10 % hemolysis at 64 μM
Hemolysis
PMID32722535;20606068;25959536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32722535/
1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 1 of 4