Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length86 amino acids

Chemical FormulaC427H695N125O119S8

DescriptionStandard

        MLLTRSSTLSGHIKLWFLTLAVLVVLAQTSPEGWFRTCFYGMGKCRHVCRANEKKKERCGENSFCCLGETKSKLSNIPTNKGRKKD
    

Molecular Weight9740.37 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)9.62

Net Charge (pH 7.4) 9.19

Charge Density (pH 7.0) 0.1119

GRAVY Index-0.36

Hydrophobic Moment 0.56

Boman Index-0.10

Instability Index40.03

Aliphatic Index 71.40

Aromaticity 0.0814

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3982.48

LogP -41.29

H-bond Donors 149.0

H-bond Acceptors 139.0

Rotatable Bonds 333.0

Heavy Atoms 679.0

Ring Count 13.0

Amide Bonds 90.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0066917 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZG4/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0112184 VERIFIED: YES