Peptide Database

Peptide Nameneuregulin-4

Function Ontology

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC289H445N77O90S7

DescriptionStandard

        MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNL
    

Molecular Weight6662.54 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-2.37

Net Charge (pH 7.4) -2.79

Charge Density (pH 7.0) -0.0389

GRAVY Index-0.22

Hydrophobic Moment 0.61

Boman Index0.07

Instability Index52.88

Aliphatic Index 60.66

Aromaticity 0.0820

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2619.91

LogP -29.66

H-bond Donors 93.0

H-bond Acceptors 97.0

Rotatable Bonds 206.0

Heavy Atoms 463.0

Ring Count 14.0

Amide Bonds 64.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0263239 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residue at position 39; predicted disulphide bond formation between cysteine residues at positions 9 and 23, 17 and 34, and 36 and 45

Bio-Activity Profile

Function

Signaling peptide

Targeterb-b2 receptor tyrosine kinase 4 (Human)