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MYP_076018
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Basic Information
Laxaphycin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
AXQNXXXPLXXVX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006419 VERIFIED: YES
Provenance & Taxonomy
Terrestrial blue-green [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Bio-Activity Profile
Antimicrobial Anticancer
CEM-WT
44 %
Inhibition
PaperPubMed PMID: 15875779 PMID15875779 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15875779/
RECORD: Rec_0027868 VERIFIED: YES
Provenance & Taxonomy
Terrestrial blue-green [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 15875779 PMID15875779 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15875779/
RECORD: Rec_0065157 VERIFIED: YES
Provenance & Taxonomy
Terrestrial blue-green [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 15875779 PMID15875779 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15875779/
RECORD: Rec_0196634 VERIFIED: YES
Provenance & Taxonomy
Terrestrial blue-green [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Bio-Activity Profile
Antimicrobial Anticancer
CEM-WT
40 %
Inhibition
PaperPubMed PMID: 15875779 PMID15875779 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15875779/
RECORD: Rec_0253460 VERIFIED: YES
Provenance & Taxonomy
Terrestrial blue-green [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Bio-Activity Profile
Antimicrobial Anticancer
CEM-VLB
44 %
Inhibition
PaperPubMed PMID: 15875779 PMID15875779 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15875779/
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