Peptide Database

Peptide NameSLAY-screened peptide P2700

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC83H112N22O22

DescriptionStandard

        TGYRFYTYNTPLHH
    

Molecular Weight1769.91 Da

Isoelectric Point (pI)8.22

Net Charge (pH 7.0)0.57

Net Charge (pH 7.4) 0.27

Charge Density (pH 7.0) 0.0407

GRAVY Index-1.13

Hydrophobic Moment 0.27

Boman Index-0.04

Instability Index-3.76

Aliphatic Index 27.86

Aromaticity 0.2857

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 716.56

LogP -5.82

H-bond Donors 26.0

H-bond Acceptors 25.0

Rotatable Bonds 49.0

Heavy Atoms 127.0

Ring Count 7.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062225 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/