Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC876H1433N221O253S12

DescriptionStandard

        KSPVHLNTTSMGMFIPQLPKLYPDMLMNLQVYATEAPMLSLQMDVVEVGAQLGAKAFAIEPNGTQVPLFTLSVETRLSGKMWIVDEKLKANAMLDNITLTLASSEVGTFKMDALENVVKMGINLMGLPKLNALLGDGIFLPQMKQAQLVNPVLKLEKGFLVVSSDTKIVQTNRNFNTL
    

Molecular Weight19493.86 Da

Isoelectric Point (pI)6.81

Net Charge (pH 7.0)-0.14

Net Charge (pH 7.4) -0.43

Charge Density (pH 7.0) -0.0008

GRAVY Index0.21

Hydrophobic Moment 0.57

Boman Index0.17

Instability Index28.28

Aliphatic Index 107.30

Aromaticity 0.0562

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7562.33

LogP -82.40

H-bond Donors 249.0

H-bond Acceptors 266.0

Rotatable Bonds 657.0

Heavy Atoms 1362.0

Ring Count 22.0

Amide Bonds 198.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0265821 VERIFIED: YES

Provenance & Taxonomy

OrganismNothobranchius pienaari [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria