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MYP_075967
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Basic Information
N-[(2S)-1-HYDROXY-3-PHENYLPROPAN-2-YL]-NALPHA-[(2E)-3-PHENYLPROP-2-ENOYL]-L-PHENYLALANINAMIDE
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Hemostasis ▸ Antithrombotic activity
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XFX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041024 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
unknown
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Reduction to amino alcohol (Pheol)
Non-proteinogenic/modified monomers: Tca
Bio-Activity Profile
-
RECORD: Rec_0044282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Amidation
HPhe- homophenylalanine, CO
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Dd2
0.0024 μM
IC50; Microscopy (Giemsa staining)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0046795 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
unknown
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Non-proteinogenic/modified monomers: Phq; Ty0
Bio-Activity Profile
-
RECORD: Rec_0070701 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Amidation
HPhe- homophenylalanine, CO
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum HB3
0.0031 μM
IC50; Microscopy (Giemsa staining)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0136289 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Amidation
HPhe- homophenylalanine, CO
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum ItG
0.0053 μM
IC50; Microscopy (Giemsa staining)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
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