Peptide Database

Peptide NameDefensin beta 118 (Beta-defensin 118)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length123 amino acids

Chemical FormulaC588H956N168O186S9

DescriptionStandard

        MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCVPSNEDHRRVPTTSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMIEESEAGRGTETSLPNVHHSS
    

Molecular Weight13643.48 Da

Isoelectric Point (pI)6.88

Net Charge (pH 7.0)-0.19

Net Charge (pH 7.4) -0.73

Charge Density (pH 7.0) -0.0015

GRAVY Index-0.46

Hydrophobic Moment 0.64

Boman Index-0.09

Instability Index54.86

Aliphatic Index 76.83

Aromaticity 0.0407

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5673.26

LogP -63.71

H-bond Donors 202.0

H-bond Acceptors 199.0

Rotatable Bonds 451.0

Heavy Atoms 951.0

Ring Count 19.0

Amide Bonds 128.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016319 VERIFIED: NO

Provenance & Taxonomy

OrganismGorilla gorilla gorilla [Animal]

FamilyBeta-defensin; Defensin

Tax ID9595

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0024487 VERIFIED: NO

Provenance & Taxonomy

OrganismGorilla gorilla gorilla [Animal]

FamilyBeta-defensin; Defensin

Tax ID9595

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetSalmonella Typhimurium

RECORD: Rec_0151658 VERIFIED: NO

Provenance & Taxonomy

OrganismGorilla gorilla gorilla [Animal]

FamilyBeta-defensin; Defensin

Tax ID9595

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0231881 VERIFIED: NO

Provenance & Taxonomy

OrganismGorilla gorilla gorilla [Animal]

FamilyBeta-defensin; Defensin

Tax ID9595

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus subtilis