Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length478 amino acids

Chemical FormulaC2339H3718N588O686S13

DescriptionStandard

        AAEDTMAVLWLLHLLVLSPLSLCTNPGITVRLTQKGLEYGRQIGIAVLQQKLKSVHIPDISGKESVSPVGSVEYSLSGMQVVSLGLPQSSLVLAPGSGLSLSIGNAYISIDGNWRVKYLKFIKDHGSFDLSVSELTISAVMAVGSDETGRPTVSCTSCSASVGSAKIKFHGGASWLYNLFSSFIDKALRNALQDKLCPLVTDAIAGINPHLKTLNVLAKVDQYAEIEYSMVSSPVITKDYIDLNLKGEFYNIGKHQEPPFPAPGFSLPAQANSMLYFGVSQFTPNSAGFVYSTTGVLSINVTDDMIPKSSPLRLNTKTFGAFIPEIAKRYPGLQMELLVKSTKQPFVTFQTNNMTLQAVGSIAAYAIQPNSTLTPLFILSVDASVSGNVYVSGVKVAGSLSLNSFKLSLVTSYVGPFQVQSLSNIFQLVLKVAVLPKVNELLQQGFPLPTIEKMNLVNTQLQIQKDYLLIGTDVQFSP
    

Molecular Weight51468.91 Da

Isoelectric Point (pI)8.47

Net Charge (pH 7.0)3.29

Net Charge (pH 7.4) 2.64

Charge Density (pH 7.0) 0.0069

GRAVY Index0.23

Hydrophobic Moment 0.72

Boman Index0.19

Instability Index37.97

Aliphatic Index 105.59

Aromaticity 0.0837

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0014512 VERIFIED: NO

Provenance & Taxonomy

OrganismLepisosteus oculatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence