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MYP_075919
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Basic Information
Cyclo(Trp-Ile), Diketopiperazine (WI)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
2 amino acids
C17H23N3O3
Standard
Sequence
WI
Physicochemical Analysis
317.38 Da
5.53
-0.24
-0.44
-0.1200
1.80
0.74
1.09
5.00
195.00
0.5000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
108.21
1.65
4.0
3.0
7.0
23.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0077744 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human fibroblasts (50% Cell death at >100 microM
100 μM
Hemolysis
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0087401 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
4 μg/mL
MIC
RECORD: Rec_0089836 VERIFIED: YES
Provenance & Taxonomy
Neobellieria bullata,Sarcophaga bullata [Animal]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme Substrate Enzyme inhibitory DPP-IV Inhibitory
Dipeptidyl peptidase IV
138.7 ± 8.0 μM
IC50
RECORD: Rec_0092818 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Proteus mirabilis MTCC 425
64 μg/mL
MIC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0111206 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human colon adenocarcinoma HCT 116
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
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