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MYP_075919
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Basic Information
Cyclo(Trp-Ile), Diketopiperazine (WI)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
2 amino acids
C17H23N3O3
Standard
Sequence
WI
Physicochemical Analysis
317.38 Da
5.53
-0.24
-0.44
-0.1200
1.80
0.74
1.09
5.00
195.00
0.5000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
108.21
1.65
4.0
3.0
7.0
23.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001528 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus MTCC 902
8 μg/mL
MIC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0014611 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa MTCC 2642
32 μg/mL
MBC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0028713 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli MTCC 2622
4 μg/mL
MBC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0031770 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
8 μg/mL
MIC
RECORD: Rec_0038442 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
138.7
IC50
PaperNongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.. In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51.
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