Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2257H3543N609O633S12

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAVLEKELAQLKLPDISGDFRLRHVVKVHYEISRLDLRSFHLPYSRISLVPNVGLQVSISNAFAEMDGNWRVKMYFVRDHGSFDLKVENVYIKINLKLGSDASGKPTIDTSDCSTRISKVRVHFSGKFGWLYNLFHSAIESRFRKILESKVCENVVSSVRNELQPYVRTLPVTARIDAMAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSTVVSPRNGGLCRCPYPLPAPLQLEKMYPDTPMKLRLSTPSAPFLNIGPGGISLKPVVDIQAYAILPNSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRYGEGAVQGGGSGGASVRMLQSIMNIFASSILLPRLNARLDQGFPLPLPDRIQLSNILVRFHPVSGGSTQPWPS
    

Molecular Weight49721.75 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)9.43

Net Charge (pH 7.4) 8.49

Charge Density (pH 7.0) 0.0207

GRAVY Index0.08

Hydrophobic Moment 0.70

Boman Index0.12

Instability Index39.63

Aliphatic Index 98.11

Aromaticity 0.0923

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0374847 VERIFIED: NO

Provenance & Taxonomy

OrganismFregetta grallaria (White-bellied storm-petrel) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria