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MYP_075881
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Basic Information
Temporin-PEb (Temporin-PE peptide derivative)
Anticancer
Anticancer ▸ Antitumor
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
23 amino acids
C124H225N45O26
Standard
Sequence
FLPIVAKLLSGLLGRKKRRQRRR
Physicochemical Analysis
2762.40 Da
12.00
8.76
8.55
0.3807
-0.57
0.55
-0.44
107.82
118.70
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1207.51
-9.75
46.0
35.0
99.0
195.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014326 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
MDA-MB-435s
3.483 μM
IC50
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0017195 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
1 μM
MIC
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0021058 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Cancer cell lines: NCI-H157
3.464 μM
IC50
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0053613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antitumor Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
2.0 μM
MIC
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0054877 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
horse red blood cells
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
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