Peptide Database

Peptide NameMet-enkephalin-Arg-Gly-Tyr

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC44H59N11O11S

DescriptionStandard

        YGGFMRGY
    

Molecular Weight950.07 Da

Isoelectric Point (pI)8.59

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0948

GRAVY Index-0.45

Hydrophobic Moment 0.46

Boman Index0.16

Instability Index-17.09

Aliphatic Index 0.00

Aromaticity 0.3750

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 369.38

LogP -2.16

H-bond Donors 14.0

H-bond Acceptors 13.0

Rotatable Bonds 28.0

Heavy Atoms 67.0

Ring Count 3.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001343 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyOpioid

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator

RECORD: Rec_0281608 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyMet-enkephalin-Arg-Gly-Tyr

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0397985 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/