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MYP_075724
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Basic Information
MCoTI-II
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C138H231N47O46S6
Standard
Sequence
GGVCPKILKKCRRDSDCPGACICRGNGYCGSGSD
Physicochemical Analysis
3476.99 Da
8.66
2.70
2.40
0.0795
-0.44
0.72
-0.15
46.36
45.88
0.0294
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1505.71
-22.38
59.0
55.0
115.0
237.0
3.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004809 VERIFIED: YES
Provenance & Taxonomy
Momordica cochinchinensis [Plant],Momordica macrophylla [Plant],Momordica sphaeroidea [Plant]
Protease inhibitor I7
3674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Escherichia coli
160 μM
MIC
PMID28669767;11434760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0118460 VERIFIED: YES
Provenance & Taxonomy
Momordica cochinchinensis [Plant],Momordica macrophylla [Plant],Momordica sphaeroidea [Plant]
Protease inhibitor I7
3674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
160 μM
MIC
PMID28669767;11434760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0158540 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Lysine rsidue labeled with Alexa-488
Cyclization
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0208654 VERIFIED: YES
Provenance & Taxonomy
Momordica cochinchinensis [Plant]
Cyclotide/MCoTI
3674
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Fluorophore labeling
Cyclization
4-21, 11-23, 17-29
N-term detail: Lysine rsidue labeled with Alexa-488; backbone cyclization reported in source
Bio-Activity Profile
Cell-penetrating peptide
RAW 264.7; MCF-7
Fluorescence-based uptake assay
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0246790 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea cv [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
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