Peptide Database

Peptide NameSLAY-screened peptide P5482

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC117H183N27O30S

DescriptionStandard

        TFTNKISFCTIITIRIVFTFN
    

Molecular Weight2479.93 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)1.39

Net Charge (pH 7.4) 1.18

Charge Density (pH 7.0) 0.0661

GRAVY Index0.99

Hydrophobic Moment 0.23

Boman Index0.33

Instability Index32.83

Aliphatic Index 106.67

Aromaticity 0.1905

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.80

LogP -7.08

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 79.0

Heavy Atoms 175.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0077679 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/