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MYP_075697
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Basic Information
L5K5W8
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C71H127N17O12
Standard
Sequence
LLKKLLKWLKK
Physicochemical Analysis
1410.87 Da
10.60
4.76
4.54
0.4323
-0.13
0.81
-0.13
-10.56
177.27
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
500.21
1.85
18.0
17.0
53.0
100.0
2.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005486 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 10031
4 μg/mL
MIC
PMID23344198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23344198/
RECORD: Rec_0032933 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Bacillus subtilis ATCC 6633 (MIC = 4microg/ml), Staphylococcus aureus ATCC 6538p (MIC = 2microg/ml), Staphylococcus epidermis ATCC 12228 (MIC = 4microg/ml), Micrococcus luteus ATCC 10240 (MIC = 4microg/ml), MRSA-TK784 (MIC = 16microg/ml), Escherichia coli ATCC 25922 (MIC = 4microg/ml), Shigella dysenteriae ATCC 9752 (MIC = 4microg/ml), Salmonella typhimurium ATCC 14028 (MIC = 4microg/ml), Klebsiella pneumoniae ATCC 10031 (MIC = 4microg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC = 8microg/ml)
128 μg/mL
MHC
PMID23344198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23344198/
RECORD: Rec_0036513 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 10031
4 μg/mL
MIC
PaperStructural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities. Molecules. 2013 Jan 11;18(1):859-876. doi: 10.3390/molecules18010859. PMID: 23344198. PMID23344198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23344198/
RECORD: Rec_0049453 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermis ATCC 12228
4 μg/mL
MIC
PaperStructural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities. Molecules. 2013 Jan 11;18(1):859-876. doi: 10.3390/molecules18010859. PMID: 23344198. PMID23344198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23344198/
RECORD: Rec_0088446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538p
2 μg/mL
MIC
PMID23344198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23344198/
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