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MYP_075637
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Basic Information
Juruin
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
38 amino acids
C172H280N48O50S6
Standard
Sequence
FTCAISCDIKVNGKPCKGSGEKKCSGGWSCKFNVCVKV
Physicochemical Analysis
4012.74 Da
9.08
4.70
4.39
0.1236
-0.04
0.32
0.02
14.64
53.68
0.0789
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1591.09
-19.13
61.0
61.0
136.0
276.0
5.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0321195 VERIFIED: YES
Provenance & Taxonomy
Avicularia juruensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-24, 7-30, 16-35
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans MDM8
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02439
RECORD: Rec_0325446 VERIFIED: YES
Provenance & Taxonomy
Avicularia juruensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-24, 7-30, 16-35
Bio-Activity Profile
Antimicrobial Antifungal
tropicalis IOC 45608
2.5-5 μM
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02439
RECORD: Rec_0327828 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0328330 VERIFIED: YES
Provenance & Taxonomy
Avicularia juruensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-24, 7-30, 16-35
Bio-Activity Profile
Antimicrobial Antifungal
human human erythrocytes
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02439
RECORD: Rec_0350690 VERIFIED: YES
Provenance & Taxonomy
Toe spider [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23103587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23103587/
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