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MYP_075614
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
34 amino acids
C172H289N61O42S6
Standard
Sequence
GRCVCRKQLLCSYRERRIGDCKIRGVRFPFCCPR
Physicochemical Analysis
4075.91 Da
9.99
7.70
7.40
0.2265
-0.45
0.71
-0.38
36.10
62.94
0.0882
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1711.43
-17.23
70.0
56.0
136.0
281.0
5.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0231861 VERIFIED: NO
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
9986
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-32; 5-21; 11-31
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0289467 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bridges: 3,32; 5,21; 11,31
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus strains 566, 502A, J.F. (reduction 0.3-1.7 logs), Staphylococcus epidermidis UCLA-622 (reduction 1.7 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A
PaperPrimary structures of six antimicrobial peptides of rabbit peritoneal neutrophils
RECORD: Rec_0308952 VERIFIED: NO
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
9986
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperNeutrophil antibiotic peptide NP-3B Evidence URLhttps://www.uniprot.org/uniprotkb/P07468/entry
RECORD: Rec_0325570 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSelsted M. E., Brown D. M, DeLange R. J., Harwig S. S., Lehrer R. I.. Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J. Biol. Chem., 260, 4579-4584, 1985.
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