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MYP_075604
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Basic Information
peptide 23
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
20 amino acids
C114H205N51O23
Standard
Sequence
LQQLLAIHFRIGRRRRRRRR
Physicochemical Analysis
2658.18 Da
12.00
8.85
8.59
0.4424
-1.30
0.60
-0.83
236.90
102.50
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1288.18
-12.40
51.0
33.0
95.0
188.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006431 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.18±0.03 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0134031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0172225 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
0.34±0.06 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0215673 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.34±0.06 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0301471 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Integrase inhibition
inhibition of strand transfer catalyzed by integrase
0.18±0.03 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/