Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length401 amino acids

Chemical FormulaC1989H3165N505O571S14

DescriptionStandard

        TFLHMSHMYTSMLLHAWLLLVALTTLTSGLNPGVKVKLTQKGLEYGRELGIASIQQKLKTIKLPDVSGSQKVNPIGKVSYSFTNMHIINVGLPQSAVSLVPGAGIKLSIGNAYLSLNGNWRVKYLKFIGSFDLSVSGLSITTTVAVNSDETGRPTFKVNSQSDNSVLLLSSWLYNLFKDFIAKALRSALEKQVKQLQLSVLQETSVLAKVDEYAEIQYSLVSSPVISTTSVDLSLKVNYSHQEPPFIPNVFSMPPESNNMLYLGLSSYTANSAGFVYTTAGALSLYITDDMVSFFTVSPIRLNTQTFGAFIPQVTSLCSLFANLVTAFCHNEPIVKARSFALFNYRLPNASPGYPLPTIGKMKLVNTQLQIMKVSARSFIKKGLVTVAGSDAPLLCCRITC
    

Molecular Weight43737.36 Da

Isoelectric Point (pI)9.43

Net Charge (pH 7.0)12.87

Net Charge (pH 7.4) 12.22

Charge Density (pH 7.0) 0.0321

GRAVY Index0.23

Hydrophobic Moment 0.69

Boman Index0.17

Instability Index31.39

Aliphatic Index 103.77

Aromaticity 0.0923

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310986 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence