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MYP_075462
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Basic Information
Lycosin-I
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C136H223N37O30S
Standard
Sequence
RKGWFKAMKSIAKFIAKEKLKEHL
Physicochemical Analysis
2888.52 Da
10.39
5.85
5.58
0.2436
-0.61
0.70
-0.17
-5.29
77.50
0.1250
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1115.96
-4.76
40.0
38.0
105.0
204.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0323310 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
PaperPatent US 2011/0319336 A2 Evidence URLhttps://patents.google.com/patent/US20110319336A2/en PatentUS 2011/0319336 A2
RECORD: Rec_0356666 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa non-MDRPA
10 μg/mL
MIC
Paper抗菌肽lycosin-I对铜绿假单胞菌临床分离株的体外抗菌活性分析; In vitro antibacterial activity analysis of antibacterial peptide lycosin-I against clinical isolates of Pseudomonas aeruginosa. [J].临床检验杂志,2018,36(04):253-258. DOI:10.13602/j.cnki.jcls.2018.04.04. Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37218
RECORD: Rec_0387046 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Bacillus subtilis CGMCC1.88, B. thuringiensis Israel H14
12.5 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
RECORD: Rec_0403526 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Bacillus cereus CMCC1.126
6.2 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
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