Peptide Database

Peptide NameLycosin-I

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC136H223N37O30S

DescriptionStandard

        RKGWFKAMKSIAKFIAKEKLKEHL
    

Molecular Weight2888.52 Da

Isoelectric Point (pI)10.39

Net Charge (pH 7.0)5.85

Net Charge (pH 7.4) 5.58

Charge Density (pH 7.0) 0.2436

GRAVY Index-0.61

Hydrophobic Moment 0.70

Boman Index-0.17

Instability Index-5.29

Aliphatic Index 77.50

Aromaticity 0.1250

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1115.96

LogP -4.76

H-bond Donors 40.0

H-bond Acceptors 38.0

Rotatable Bonds 105.0

Heavy Atoms 204.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0219901 VERIFIED: YES

Provenance & Taxonomy

OrganismLycosa singoriensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis

RECORD: Rec_0248579 VERIFIED: YES

Provenance & Taxonomy

OrganismLycosa singoriensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

RECORD: Rec_0312949 VERIFIED: NO

Provenance & Taxonomy

OrganismLycosa singoriensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

RECORD: Rec_0313560 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anticancer Toxic Anti-Gram-positive Cytotoxic Anti-Gram-negative

RECORD: Rec_0323247 VERIFIED: YES

Provenance & Taxonomy

OrganismLycosa singoriensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetPseudomonas aeruginosa MDRPA

Activity12 μg/mL

MethodMIC

Paper抗菌肽lycosin-I对铜绿假单胞菌临床分离株的体外抗菌活性分析; In vitro antibacterial activity analysis of antibacterial peptide lycosin-I against clinical isolates of Pseudomonas aeruginosa. [J].临床检验杂志,2018,36(04):253-258. DOI:10.13602/j.cnki.jcls.2018.04.04. Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37218

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