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MYP_075462
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Basic Information
Lycosin-I
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C136H223N37O30S
Standard
Sequence
RKGWFKAMKSIAKFIAKEKLKEHL
Physicochemical Analysis
2888.52 Da
10.39
5.85
5.58
0.2436
-0.61
0.70
-0.17
-5.29
77.50
0.1250
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1115.96
-4.76
40.0
38.0
105.0
204.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0095312 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
51, Pseudomonas aeruginosa CMCC10104, Salmonella Typhimurium CGMCC1.1174, E. aerogenes CGMCC1.2021, A. wieringae CGMCC1.2033, A. faecalis CGMCC1.924, Klebsiella pneumoniae CPCC160022, E. cloacae CGMCC1.58
50 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
RECORD: Rec_0100664 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Cationic peptide 04 (cupiennin); 05 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Antiparasitic Antiplasmodial Anti-Gram-negative Anticancer Non-hemolytic
Candida species
PMID22882120;23638903;25199777;26937786;28839471;30269852;29248696;30682337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22882120/
RECORD: Rec_0136834 VERIFIED: YES
Provenance & Taxonomy
Wolf spider [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22677064 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22677064/
RECORD: Rec_0144954 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Antiprotozoal
Active against Toxoplasma gondii
PMID30682337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30682337/
RECORD: Rec_0201545 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Cationic peptide 04 (cupiennin); 05 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Antiparasitic Antiplasmodial Anti-Gram-negative Anticancer Non-hemolytic
Acinetobacter baumannii
PMID22882120;23638903;25199777;26937786;28839471;30269852;29248696;30682337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22882120/
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