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MYP_075462
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Basic Information
Lycosin-I
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C136H223N37O30S
Standard
Sequence
RKGWFKAMKSIAKFIAKEKLKEHL
Physicochemical Analysis
2888.52 Da
10.39
5.85
5.58
0.2436
-0.61
0.70
-0.17
-5.29
77.50
0.1250
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1115.96
-4.76
40.0
38.0
105.0
204.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046290 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
B. bassiana CGMCC3.3576
6.2 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
RECORD: Rec_0046840 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Cationic peptide 04 (cupiennin); 05 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Antiparasitic Antiplasmodial Anti-Gram-negative Anticancer Non-hemolytic
Toxoplasma gondii
PMID22882120;23638903;25199777;26937786;28839471;30269852;29248696;30682337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22882120/
RECORD: Rec_0051987 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Escherichia coli CGMCC1.1369
25 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
RECORD: Rec_0056266 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
fungi Penicillium ACCC30106, A. flavus CGMCC3.6433
3.1 μM
MIC
PaperA novel spider peptide toxin suppresses tumor growth through dual signaling pathways.
RECORD: Rec_0087067 VERIFIED: YES
Provenance & Taxonomy
Lycosa singorensis [Animal]
Lycosin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
PaperCurr Mol Med. 2012 Dec;12(10):1350-60 | http://www.ncbi.nlm.nih.gov/pubmed/22882120 PMID22882120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22882120/
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