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MYP_075445
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
3 amino acids
C23H35N5O4
Standard
Sequence
IKW
Physicochemical Analysis
445.56 Da
8.75
0.76
0.55
0.2530
-0.10
0.65
0.23
-21.63
130.00
0.3333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
163.33
1.27
6.0
5.0
13.0
32.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0263645 VERIFIED: YES
Provenance & Taxonomy
Arachis hypogaea [Plant]
Arachin
3818
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme
19 μM
IC50
PaperPubMed PMID 20214946 PMID20214946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20214946/
RECORD: Rec_0281834 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
0.21
IC50
PaperFujita H., Yokoyama K., Yoshikawa M.. Classification of antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci., 65, 564-569, 2000.
RECORD: Rec_0398819 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperWang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.. Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024.
RECORD: Rec_0400094 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
0.21 μM
IC50
PaperInhibition strength of short peptides derived from an ACE inhibitory peptide. PMID21923188 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21923188/
RECORD: Rec_0405256 VERIFIED: NO
Provenance & Taxonomy
Gallus gallus [Animal]
ACE-inhibitory peptide
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
0.32-14 μM
IC50
PaperISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS. PMID24915368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24915368/
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