Peptide Database

Peptide NamePanitide L8

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC109H169N27O39S6

DescriptionStandard

        QDCGETCVLGTCYTPGCSCSAYPLCV
    

Molecular Weight2674.06 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.30

Net Charge (pH 7.4) -2.59

Charge Density (pH 7.0) -0.0884

GRAVY Index0.45

Hydrophobic Moment 0.19

Boman Index0.22

Instability Index19.08

Aliphatic Index 56.15

Aromaticity 0.0769

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1032.54

LogP -13.94

H-bond Donors 41.0

H-bond Acceptors 43.0

Rotatable Bonds 78.0

Heavy Atoms 181.0

Ring Count 4.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0002415 VERIFIED: YES

Provenance & Taxonomy

OrganismPanicum laxum [Plant]

FamilyCyclotide

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Other ModsN-terminal pyroglutamate

Bio-Activity Profile

Function

Antimicrobial Cytotoxic

TargetHeLa cells

RECORD: Rec_0257977 VERIFIED: YES