Peptide Database

Peptide NameCyclotide varv A

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC117H187N35O40S7

DescriptionStandard

        CETCVGGTCNTPGCSCSWPVCTRNGLPVC
    

Molecular Weight2948.40 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.31

Net Charge (pH 7.4) -0.61

Charge Density (pH 7.0) -0.0106

GRAVY Index0.25

Hydrophobic Moment 0.31

Boman Index0.14

Instability Index44.01

Aliphatic Index 43.45

Aromaticity 0.0345

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1174.30

LogP -18.35

H-bond Donors 47.0

H-bond Acceptors 47.0

Rotatable Bonds 85.0

Heavy Atoms 199.0

Ring Count 5.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0121541 VERIFIED: YES

Provenance & Taxonomy

OrganismViola tricolor [Plant]

FamilyCyclotide

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Cytotoxic

TargetU-937 GTB

Activity6 μM

MethodIC50

RECORD: Rec_0318837 VERIFIED: YES

Provenance & Taxonomy

OrganismViola tricolor [Plant]

FamilyCyclotide

Tax ID214053

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Cytotoxic