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MYP_075367
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Basic Information
Mela 2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C132H208N34O41S6
Standard
Sequence
GKPTCGETCFKGKCYTPGCTCSYPLCKKD
Physicochemical Analysis
3119.66 Da
8.63
2.70
2.40
0.0931
-0.60
0.26
-0.09
3.06
13.45
0.1034
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1198.06
-14.72
47.0
50.0
98.0
213.0
6.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0282801 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0329696 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Anti-Gram-negative
Escherichia coli
PaperPubMed PMID 26322745 | Ravipati et al. 2015 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0352895 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic
Human skin melanoma MM96L
1.30±0.44 μM
IC50
PaperPubMed PMID 26322745 | Ravipati et al. 2015 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0397038 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
19.26±1.37 μM
CC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
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