Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2286H3559N601O630S10

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGIAVLQKELARLKLPDISGDFPVRHVGKVHYEISSLDLRSFHLPYSRISLVPGVGLQVSISSAFAEVDGNWRVKFYFIRDHGSFNLEVANVYIKIDLKLGSDASGKPTVSTSACSTHISSVHVHFSGKFGWLYNLFYSVVASRFRKILESKVCESVVISVGTDLQRYLQTLPVTARIDARAGIDYSLVAPPAATAQSLDVGLKGEFFSLAHRAAVPFPPPALALPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDAMIPKDVEFHLNTTTFAAFIPQLEEMYPNMLMKLRLSAPSAPFLSIGPGGLSLQPVVDIQAYAILPSASLAPLFLLSLVSNVSATINVKSGHIVGSLSVGRMKLSLKHSDVGTFKVRMLQSIMNTYASSILLPHVNERLGEGFPLPLPDRIQLSNILVRFHQNFLLLGADVHYTPR
    

Molecular Weight49862.01 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)5.97

Net Charge (pH 7.4) 4.76

Charge Density (pH 7.0) 0.0131

GRAVY Index0.23

Hydrophobic Moment 0.65

Boman Index0.18

Instability Index36.84

Aliphatic Index 103.27

Aromaticity 0.1009

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 34965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0372294 VERIFIED: NO

Provenance & Taxonomy

OrganismPenelope pileata [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria