Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC165H282N46O57

DescriptionStandard

        PISLERLDVGTNLGNAIAKLEDAKELLESSDQILR
    

Molecular Weight3822.28 Da

Isoelectric Point (pI)4.44

Net Charge (pH 7.0)-3.03

Net Charge (pH 7.4) -3.10

Charge Density (pH 7.0) -0.0865

GRAVY Index-0.22

Hydrophobic Moment 0.65

Boman Index-0.03

Instability Index23.23

Aliphatic Index 128.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1685.86

LogP -17.21

H-bond Donors 58.0

H-bond Acceptors 54.0

Rotatable Bonds 135.0

Heavy Atoms 268.0

Ring Count 1.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0228411 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetmeasles virus(MV):protection of HEp2 cell from viral cytopathic effect(CPE)

Activity3.1 μg/mL

MethodEC50

RECORD: Rec_0322218 VERIFIED: YES

Provenance & Taxonomy

OrganismMeasles morbillivirus [Virus]

FamilyVirus-derived peptide

Tax ID11234;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Cytoprotective

TargetMeasles virus (Fusion); HEp2

Activity3.1 μM

MethodEC50

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

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