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MYP_075206
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Basic Information
HPIV3 F HRC derived peptide(442-486)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
45 amino acids
C218H362N62O77
Standard
Sequence
DITLNNSVALDPIDISIELNKAKSDLEESKEWIRRSNQKLDSIGN
Physicochemical Analysis
5083.58 Da
4.56
-3.23
-3.45
-0.0717
-0.70
0.66
-0.16
54.31
106.22
0.0222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2314.45
-26.35
78.0
74.0
179.0
357.0
3.0
50.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025498 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of fusion in HeLa cells
0.5 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 Oct;80(19):9837-49. | DOI:10.1128/JVI.00736-06 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0028139 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 57.8%, E 0.0%, T 8.9%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0049204 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of fusion in HeLa cells
0.0075 μM
IC50
PaperPubMed PMID: 16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0072294 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
human parainfluenza virus 3 (HPIV3) | HeLa cells
0.5 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 Oct;80(19):9837-49. | DOI:10.1128/JVI.00736-06 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0145072 VERIFIED: YES
Provenance & Taxonomy
Human parainfluenza virus 3 [Virus]
Virus-derived peptide
11216;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Human parainfluenza virus type 3 (Fusion); HeLa
0.5 μM
Luminescence fusion assay
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
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