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MYP_075028
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Basic Information
Antimicrobial peptide scolopin-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C118H189N35O29S
Standard
Sequence
FLPKMSTKLRVPYRRGTKDYH
Physicochemical Analysis
2594.05 Da
10.55
4.84
4.58
0.2306
-1.13
0.57
-0.35
86.46
50.95
0.1429
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1058.63
-8.25
39.0
36.0
84.0
183.0
6.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004062 VERIFIED: YES
Provenance & Taxonomy
Scolopendra mutilans [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Gram-negative and Gram-positive bacteria
PMID19716842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19716842/
RECORD: Rec_0010892 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0026167 VERIFIED: YES
Provenance & Taxonomy
Scolopendra subspinipes mutilans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
resistant Escherichia coli
15
MIC
PaperTwo novel antimicrobial peptides from centipede venoms.
RECORD: Rec_0040267 VERIFIED: YES
Provenance & Taxonomy
Scolopendra subspinipes mutilans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
12.5 μg/mL
MIC
PaperTwo novel antimicrobial peptides from centipede venoms.
RECORD: Rec_0048980 VERIFIED: YES
Provenance & Taxonomy
Scolopendra subspinipes mutilans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-positive Anti-Gram-negative
Escherichia coli standard strain
12.5 μg/mL
MIC
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