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MYP_074968
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Basic Information
Ranacyclin-E
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C85H132N24O22S2
Standard
Sequence
SAPRGCWTKSYPPKPCK
Physicochemical Analysis
1906.24 Da
9.70
3.44
3.19
0.2021
-1.22
0.26
-0.25
26.12
5.88
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
730.43
-7.62
27.0
28.0
54.0
133.0
7.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0164537 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas syringae pv tabaci
80 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0176184 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Antifungal Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0184954 VERIFIED: YES
Provenance & Taxonomy
Pelophylax lessonae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Antifungal Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
C. tropicalis (Gram-negative)
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0196701 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond
Bio-Activity Profile
Antimicrobial Antifungal
P. nicotianae spores
32 μM
MIC
PaperRanacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity.
RECORD: Rec_0216067 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond
Bio-Activity Profile
Antimicrobial Antifungal
C. tropicalis
7.4 μM
MIC
PaperRanacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity.
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