Peptide Database

Peptide NameRanacyclin-E

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC85H132N24O22S2

DescriptionStandard

        SAPRGCWTKSYPPKPCK
    

Molecular Weight1906.24 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.19

Charge Density (pH 7.0) 0.2021

GRAVY Index-1.22

Hydrophobic Moment 0.26

Boman Index-0.25

Instability Index26.12

Aliphatic Index 5.88

Aromaticity 0.1176

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 730.43

LogP -7.62

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 54.0

Heavy Atoms 133.0

Ring Count 7.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067801 VERIFIED: YES

Provenance & Taxonomy

OrganismRana esculenta [Animal]

FamilyRanacyclin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida tropicalis

Activity7.4 μM

MethodMIC

RECORD: Rec_0068682 VERIFIED: YES

Provenance & Taxonomy

OrganismPelophylax lessonae [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetP. nicotianae (Gram-positive)

RECORD: Rec_0080647 VERIFIED: YES

Provenance & Taxonomy

OrganismPelophylax lessonae [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetY. pseudotuberculosis (Gram-negative)

RECORD: Rec_0092730 VERIFIED: YES

Provenance & Taxonomy

OrganismRana esculenta [Animal]

FamilyRanacyclin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetP.nicotianae spores

Activity32 μM

MethodMIC

RECORD: Rec_0107821 VERIFIED: YES

Provenance & Taxonomy

OrganismRana esculenta [Animal]

FamilyRanacyclin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetY.pseudotuberculosis YP III

Activity9 μM

MethodMIC

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