‹ ›
MYP_074920
← PREVIOUS NEXT → BACK
Basic Information
Ascaphin-8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C97H163N23O23
Standard
Sequence
GFKDLLKGAAKALVKTVLF
Physicochemical Analysis
2019.47 Da
10.00
2.76
2.55
0.1451
0.74
0.68
0.24
-13.36
128.42
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
748.73
-3.20
26.0
26.0
70.0
143.0
2.0
18.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0076970 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 52.6%, E 0.0%, T 31.6%, C 15.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Antifungal
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0081232 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
C4-2B
42.91 μM
IC50
PMID15207717;33932712;23094651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0083160 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Ascaphus truei [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
Escherichia coli
6 μM
MIC
PaperThe ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei.
RECORD: Rec_0085812 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 11 and 15) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (11) and Ⓚ (15) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
128 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0087195 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 3 and 7) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (3) and Ⓚ (7) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus (MRSA)
16 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
FIRST PREV 1 2 3 4 5 ... 16 NEXT LAST
Showing 5 records on this page · Page 3 of 16