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MYP_074920
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Basic Information
Ascaphin-8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C97H163N23O23
Standard
Sequence
GFKDLLKGAAKALVKTVLF
Physicochemical Analysis
2019.47 Da
10.00
2.76
2.55
0.1451
0.74
0.68
0.24
-13.36
128.42
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
748.73
-3.20
26.0
26.0
70.0
143.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0282982 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 11 and 15) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (11) and Ⓚ (15) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus (MRSA)
8 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0286792 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Ascaphus truei [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
Enterococcus faecalis
50 μM
MIC
PaperThe ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei.
RECORD: Rec_0290454 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0297770 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 3 and 7) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (3) and Ⓚ (7) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
cephalosporin-resistant Escherichia coli
32 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0303433 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ascaphin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 7 and 11) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (7) and Ⓚ (11) are cross-linked by a (E)-but-2-enyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus (MRSA)
8 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
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