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MYP_074881
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Basic Information
CA(1-7)M(2-9)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C89H151N21O16
Standard
Sequence
KWKLFKKIGAVLKVL
Physicochemical Analysis
1771.28 Da
10.60
4.76
4.54
0.3170
0.54
0.69
0.15
-28.99
149.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
616.61
0.94
22.0
21.0
63.0
126.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0100268 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Myristoyl at 1st lysine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
0.8 μM
LD50; MTT assay
PaperN-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide PMID11502512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11502512/
RECORD: Rec_0100317 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 66.7%, E 0.0%, T 13.3%, C 20.0% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Hemolytic Antileishmanial
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0103642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
WM1158
4.1 μM
LC50
PMID20212453 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20212453/
RECORD: Rec_0126509 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Lauryl at 7th lysine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antileishmanial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0130238 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Acetyl at 1st lysine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (amastigote)
12.1 μM
LD50; MTT assay
PaperN-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide PMID11502512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11502512/
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