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MYP_074881
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Basic Information
CA(1-7)M(2-9)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C89H151N21O16
Standard
Sequence
KWKLFKKIGAVLKVL
Physicochemical Analysis
1771.28 Da
10.60
4.76
4.54
0.3170
0.54
0.69
0.15
-28.99
149.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
616.61
0.94
22.0
21.0
63.0
126.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0386244 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Myristoyl at 7th lysine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
32.1 μM
LD50; MTT assay
PaperN-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide PMID11502512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11502512/
RECORD: Rec_0393786 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic Antimicrobial Antileishmanial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0397438 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CAMEL/cecropin-melittin hybrid peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
WM1158 (skin cancer)
4.1 μM
LC50
PaperAnticancer effects of CAMEL peptide | https://pubmed.ncbi.nlm.nih.gov/20212453/ PMID20212453 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20212453/
RECORD: Rec_0399109 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
1 μM
MIC
PaperPubMed PMID: 1733777 | PubMed PMID: 17397158 PMID1733777;17397158 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733777/
RECORD: Rec_0400795 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Sheep erythrocytes
164 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/20617807/ PMID20617807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20617807/
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