‹ ›
MYP_074881
← PREVIOUS NEXT → BACK
Basic Information
CA(1-7)M(2-9)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C89H151N21O16
Standard
Sequence
KWKLFKKIGAVLKVL
Physicochemical Analysis
1771.28 Da
10.60
4.76
4.54
0.3170
0.54
0.69
0.15
-28.99
149.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
616.61
0.94
22.0
21.0
63.0
126.0
3.0
14.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0343257 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin-Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antifungal
Candida albicans
18 μM
MIC
PaperCan BioSAXS detect ultrastructural changes of antifungal compounds in Candida albicans?-an exploratory study PMID37533629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37533629/
RECORD: Rec_0343610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa
3.615 μM
OD600
RECORD: Rec_0349083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
4.4 μM
LD50; MTT assay
PaperN-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide PMID11502512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11502512/
RECORD: Rec_0350018 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus aureus ATCC 43300
0.452 μM
Crystal violet assay
RECORD: Rec_0350034 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Trimethylation
Amidation
Lysine Nepsilon-Trimethylation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani 3Luc (promastigote)
>50 μM
IC50; MTT assay
PaperLysine N(epsilon)-trimethylation, a tool for improving the selectivity of antimicrobial peptides PMID20617807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20617807/
FIRST PREV 1 ... 17 18 19 20 21 22 NEXT LAST
Showing 5 records on this page · Page 19 of 22