MYP_074881
CA(1-7)M(2-9)
Anticancer
Anticancer
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Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-negative
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Antimicrobial
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Antibacterial
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Anti-Mycobacterium
Antimicrobial
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Anti-biofilm
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Biofilm inhibition
Antimicrobial
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Antifungal
Antiparasitic
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Anti-Leishmania
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Antileishmanial
Antiparasitic
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Antimalarial
Antiparasitic
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Antiprotozoal
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Antimalarial
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Anti-Plasmodium
Antiparasitic
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General antiparasitic
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Antiparasitic
Toxicity / Safety
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Blood cell toxicity
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Hemolysis
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Hemolytic
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Venom / Toxin
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General toxin
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Toxic
Standard
15 amino acids
C89H151N21O16
Standard
KWKLFKKIGAVLKVL
1771.28 Da
10.60
4.76
4.54
0.3170
0.54
0.69
0.15
-28.99
149.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
616.61
0.94
22.0
21.0
63.0
126.0
3.0
14.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0215919
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm
Antibacterial
Pseudomonas aeruginosa
36.155, 3.615, 0.362 μM
OD600
RECORD: Rec_0217690
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Octanoyl at 1st lysine
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Antiparasitic
Antileishmanial
Leishmania donovani MHOM/SD/00/1S-2D (promastigote)
1.1 μM
LD50; MTT assay
RECORD: Rec_0228033
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
[Refer PubMed ID - 31448597: Escherichia coli (ATCC 25922)
2 μM
MIC
RECORD: Rec_0235189
VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Other derivatives [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
bacteria: The peptide forms pore on membranes. Structure: helical in 20% hexafluoroisopropanol (HFIP). You can rotate, zoom, and view the 3D structure bound to DPC micelles here in the PDB. In vitro toxicity: sheep RBC (LC >300 uM), not hemo.lytic. Surface immobilized peptide: It has been surface immobilized 2016 onto gold nanoparticles at a high density of 110 ug/cm2 with a braod activity spectrum (Rai A et al., 2016). Chemical modification: Succinylation of the amino acids at the N-terminus and lysine side chains inhibits the effect of this peptide on liposome permeability. This modification appears to block the formation of helical structure in liposome. Updated Jan2025
Bio-Activity Profile
Antimicrobial
Antiparasitic
Klebsiella pneumoniae ATCC 700603
0.125 μg/mL
MIC
RECORD: Rec_0238420
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Palmitoyl at 7th lysine
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Antiparasitic
Antileishmanial
Showing 5 records on this page · Page 13 of 22