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MYP_074775
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
14 amino acids
C65H112N18O23
Standard
Sequence
AGERIVDIIATDIQ
Physicochemical Analysis
1513.69 Da
4.05
-2.20
-2.39
-0.1571
0.44
0.63
0.17
-12.90
146.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
678.74
-6.06
23.0
21.0
51.0
106.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0136662 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 28.6%, C 71.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0138702 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
2 μM
IC50
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0322477 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
2 μM
IC50
PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0334688 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
2 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. | Zhao L, O'Reilly MK, Shultz MD, Chmielewski J. | Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7. | DOI:10.1016/s0960-894x(03)00040-4 | PMID:12643937 PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/