Peptide Database

Peptide NameSLAY-screened peptide P925

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H167N33O34S

DescriptionStandard

        YNRDDYFRNYHYRCLYPTLS
    

Molecular Weight2659.89 Da

Isoelectric Point (pI)8.14

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0417

GRAVY Index-1.37

Hydrophobic Moment 0.41

Boman Index-0.33

Instability Index51.16

Aliphatic Index 39.00

Aromaticity 0.3000

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1124.20

LogP -9.05

H-bond Donors 42.0

H-bond Acceptors 37.0

Rotatable Bonds 79.0

Heavy Atoms 189.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021521 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/