Peptide Database

Peptide NameSLAY-screened peptide P3252

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC124H163N29O32S3

DescriptionStandard

        DYPNTYEFMPYNRWCYRAFM
    

Molecular Weight2667.99 Da

Isoelectric Point (pI)6.06

Net Charge (pH 7.0)-0.25

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0125

GRAVY Index-0.96

Hydrophobic Moment 0.53

Boman Index-0.08

Instability Index49.81

Aliphatic Index 5.00

Aromaticity 0.3500

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1000.16

LogP -4.92

H-bond Donors 36.0

H-bond Acceptors 35.0

Rotatable Bonds 76.0

Heavy Atoms 188.0

Ring Count 10.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0219778 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/