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MYP_074679
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Alanine Carboxypeptidase Inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Renin inhibition ▸ Renin inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Tubulin-Tyrosine Ligase Inhibitor
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C12H16N2O4
Standard
Sequence
YA
Physicochemical Analysis
252.27 Da
5.52
-0.24
-0.45
-0.1205
0.25
0.31
0.44
123.40
50.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
-0.15
4.0
4.0
5.0
18.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
A* = Cαα -dialkylated glycine (Aaa1,1 )
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
8.2 %
Inhibition
PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0354454 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
A* = Cαα -dialkylated glycine (Aaa1,1 )
Bio-Activity Profile
Anticancer Antitumor
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0355062 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial
recombinant Escherichia coli surface-display screening
SLAY screening
PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/
RECORD: Rec_0379587 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
3.34 pIC50
pIC50
PaperThree-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides. PMID17654623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17654623/
RECORD: Rec_0407441 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
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