Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2458H3860N658O684S18

DescriptionStandard

        MSNLDLSTMMWVLFLPIFESHLFLKKEPKPPGALKLQITQRGLAYAKTVGMELLLSQLRKQPMPDQCSTYNVPHLDEISWSFSNIQIKQLQVKDSEASFAKDKGVRLAIRNAQIVFTSNWTIKHLFGQDKGTLQTDIAVRSLSVLLGLDVDDGGWPVVRTLSCSADLLDFELMFNGLNSGFYNWISQGIKRTLISDFNQEVCIEVKKSVDHFSHNLRNAEFWTQIDPIAGFNYSLVSKPEIAEDRCNLDFKGEFFLMERHQKSPLVPTPIVLPKRSSSMVVIGISDFLVNSAAFVYFSGNMLRVKYTNKTIPKRVPFSAFRLNTQHIGSLFPELKRQFPKMPMELHLAAQKEPKLHFHPGGLDAIVLGRAEVFVVLPNSSLVPVFTLNVDCNFTGQIFLEGVRSGNSFAKVRGSVALKGLRLSQAWSSIGEIKLSPLETLLKIAGNVALSAHNRESRDPSPPFPGGITPPAMAGCGGARASWRPFS
    

Molecular Weight54150.11 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)11.45

Net Charge (pH 7.4) 10.48

Charge Density (pH 7.0) 0.0236

GRAVY Index-0.05

Hydrophobic Moment 0.74

Boman Index0.08

Instability Index37.97

Aliphatic Index 92.86

Aromaticity 0.0947

Extinction Coeff. Reduced 52940.00

Extinction Coeff. Oxidized 53315.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0127146 VERIFIED: NO

Provenance & Taxonomy

OrganismLaticauda laticaudata [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence