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MYP_074524
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Basic Information
Callyaerin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IXIILPPLXPII
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0129200 VERIFIED: YES
Provenance & Taxonomy
Callyspongia aerizusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,9
Bio-Activity Profile
Antimicrobial Antibacterial
Rat pheochromocytoma PC12
8 μM
ED50
PMID26213786;20599387 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26213786/
RECORD: Rec_0153979 VERIFIED: YES
Provenance & Taxonomy
Callyspongia aerizusa [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
X(2)= 4-Hydroxyproline; X(9)=Daa
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
2 μM
IC50
PaperPubMed PMID: 26213786 PMID26213786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26213786/
RECORD: Rec_0180441 VERIFIED: YES
Provenance & Taxonomy
Callyspongia aerizusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,9
Bio-Activity Profile
Cytotoxic
Human fibroblasts MRC-5
6 μM
IC90
PMID26213786;20599387 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26213786/
RECORD: Rec_0207706 VERIFIED: YES
Provenance & Taxonomy
Callyspongia aerizusa [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
X(2)= 4-Hydroxyproline; X(9)=Daa
Bio-Activity Profile
Antimicrobial Anticancer
THP-1
5 μM
IC50
PaperPubMed PMID: 26213786 PMID26213786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26213786/
RECORD: Rec_0215424 VERIFIED: YES
Provenance & Taxonomy
Callyspongia aerizusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,9
Bio-Activity Profile
Antimicrobial Antibacterial
Mycobacterium tuberculosis
5 μM
MIC90
PMID26213786;20599387 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26213786/
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