Peptide Database

Peptide NameDornase alfa

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length260 amino acids

Chemical FormulaC1321H1999N339O396S9

DescriptionStandard

        LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
    

Molecular Weight29253.62 Da

Isoelectric Point (pI)4.58

Net Charge (pH 7.0)-14.81

Net Charge (pH 7.4) -15.39

Charge Density (pH 7.0) -0.0570

GRAVY Index-0.08

Hydrophobic Moment 0.80

Boman Index0.09

Instability Index37.87

Aliphatic Index 88.88

Aromaticity 0.1231

Extinction Coeff. Reduced 45840.00

Extinction Coeff. Oxidized 46090.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0031759 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Chinese hamster ovary cell line [Animal]

FamilyEnzyme

Tax ID9606; 10029

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement

TargetCHO