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MYP_074438
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Basic Information
Brevinin-1V
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C124H209N29O28S2
Standard
Sequence
FLPLIASVAANLVPKIFCKITKKC
Physicochemical Analysis
2618.29 Da
9.70
3.74
3.50
0.1557
1.06
0.69
0.31
18.56
134.17
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
902.67
-3.68
32.0
34.0
85.0
183.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0349242 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Rhodococcus rhodochrous X15
9.5 μM
MIC
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
RECORD: Rec_0373294 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Slime mould 090223
1.2 μM
MIC
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
RECORD: Rec_0389954 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecalis 981
19 μM
MIC
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
RECORD: Rec_0395100 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperT. Chen et al. / Genomics 87 (2006) 638-644. Cloning from tissue surrogates: Antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs Evidence URLhttps://www.uniprot.org/uniprotkb/E7EKC5/entry
RECORD: Rec_0404050 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
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